Journal article
Lifetime spirometry patterns of obstruction and restriction, and their risk factors and outcomes: a prospective cohort study
SC Dharmage, DS Bui, EH Walters, AJ Lowe, B Thompson, G Bowatte, P Thomas, J Garcia-Aymerich, D Jarvis, GS Hamilton, DP Johns, P Frith, CV Senaratna, NS Idrose, RR Wood-Baker, J Hopper, L Gurrin, B Erbas, GR Washko, R Faner Show all
Lancet Respiratory Medicine | ELSEVIER SCI LTD | Published : 2023
Abstract
Background: Interest in lifetime lung function trajectories has increased in the context of emerging evidence that chronic obstructive pulmonary disease (COPD) can arise from multiple disadvantaged lung function pathways, including those that stem from poor lung function in childhood. To our knowledge, no previous study has investigated both obstructive and restrictive lifetime patterns concurrently, while accounting for potential overlaps between them. We aimed to investigate lifetime trajectories of the FEV1/forced vital capacity (FVC) ratio, FVC, and their combinations, relate these combined trajectory groups to static lung volume and gas transfer measurements, and investigate both risk f..
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Grants
Awarded by NHMRC European collaborative grant scheme, Ageing Lungs in European Cohorts - EU
Awarded by University of Melbourne
Funding Acknowledgements
We thank the Tasmanian Longitudinal Health Study (TAHS) participants. We thank TAHS investigators who were not co-authors of this manuscript for their assistance with obtaining funds and data collection. We also thank the respiratory scientists who collected data in the lung function laboratories of Tasmania, Victoria, Queensland, and New South Wales; and the research interviewers, data entry operators, and research officers. Finally, we thank the Archives Office of Tasmania for providing data from the 1968 TAHS questionnaires. TAHS was supported by the National Health and Medical Research Council (NHMRC) of Australia under NHMRC project grant schemes (299901, 1021275) and an NHMRC European collaborative grant scheme (1101313) as part of Ageing Lungs in European Cohorts funded by the EU Horizon 2020 research and innovation programme under grant agreement 633212; The University of Melbourne; Clifford Craig Medical Research Trust of Tasmania; the Victorian, Queensland & Tasmanian Asthma Foundations; The Royal Hobart Hospital; the Helen MacPherson Smith Trust; and GlaxoSmithKline. SCD, AJL, JLP, CJL, and EHW are supported by the NHMRC of Australia.